Development of infectious recombinant bk virus

BK virus: opportunity makes a pathogen. Clinical Infectious Diseases. Prevalence of polyomavirus BK and JC infection and replication in healthy blood donors. Journal of Infectious Diseases. Polyomavirus-associated nephropathy in renal transplantation: interdisciplinary analyses and recommendations.

BK virus nephritis: risk factors, timing, and outcome in renal transplant recipients. Kidney International. Comoli P, Ginevri F. Monitoring and managing viral infections in pediatric renal transplant recipients. Pediatric Nephrology. BK virus infection, replication, and diseases in pediatric kidney transplantation. American Journal of Transplantation. Hirsch H, Randhawa P. AST infectious diseases community of practice. BK polyomavirus in solid organ transplant recipients. Ratio between Epstein-Barr viral load and anti-Epstein-Barr virus specific T-cell response as a predictive marker of posttransplant lymphoproliferative disease.

Cellular immunotherapy for viral infections in solid organ transplantation. Current Opinion in Organ Transplantation. BK virus-specific T cells for use in cellular therapy show specificity to multiple antigens and polyfunctional cytokine responses.

Antigen-specific T cell responses to BK polyomavirus antigens identify functional anti-viral immunity and may help to guide immunosuppression following renal transplantation. Clinical and Experimental Immunology. Histological patterns of polyomavirus nephropathy: correlation with graft outcome and viral load. Prospective study of polyomavirus type BK replication and nephropathy in renal-transplant recipients.

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Healthy individuals generate a predominantly CD4 cell reponse against polyomavirus BK. Viral Immunology. Novel approach for improved assessment of phenotypic and functional characteristics of BKV-specific T-cell immunity. Human polyomavirus type 1 BK virus agnoprotein is abundantly expressed but immunologically ignored. Clinical and Vaccine Immunology. Clinical and Developmental Immunology. Humoral and cellular immunity to polyomavirus BK large T and VP1 antigens after pediatric kidney transplantation.

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Use of gene-modified virus-specific T lymphocytes to control Epstein-Barr-virus-related lymphoproliferation. The Lancet. Infusion of autologous Epstein-Barr virus EBV -specific cytotoxic T cells for prevention of EBV-related lymphoproliferative disorder in solid organ transplant recipients with evidence of active virus replication. Dendritic cells pulsed with polyomavirus BK antigen induce ex vivo polyoma BK virus-specific cytotoxic T-cell lines in seropositive healthy individuals and renal transplant recipients.

Journal of the American Society of Nephrology. Human Immunology. Phylogenetic analysis of polyomavirus BK sequences. Journal of Virology. T-cell responses to peptide fragments of the BK virus T antigen: implications for cross-reactivity of immune response to JC virus.

Journal of General Virology. Polyomavirus JC-targeted T-cell therapy for progressive multiple leukoencephalopathy in a hematopoietic cell transplantation recipient. Bone Marrow Transplantation. A review of JC virus infection in kidney transplant recipients. Effect of dose and long-term storage on the immunogenicity of murine polyomavirus VP1 virus-like particles.

Development of infectious recombinant BK virus. Virus Research. Abstract 1. Introduction 2. Treatment Treatment of hemorrhagic cystitis is according to the local standard operating procedures, depending on the cause and severity [ 6 , 11 ]. Table 2 Clinical trials for HC.

Conservative therapy Conservative therapies, also known as supportive approaches or symptomatic therapies, are considered as preventive and the first steps of therapy in most centers. Complimentary options In more severe cases grades 2 and 3 HC , complimentary options described below are used: - Optimization of the hematological homeostasis including the use of clotting factors recombinant factor VIIa or VIII, factor XIII and antifibrinolytic agent aminocapronic acid [ 6 , 11 ]. Surgical procedures In very severe cases, as last step of treatment, urological intervention and surgical management such as bilateral percutaneous nephrostomy tubes with or without ureteral occlusion, selective arterial embolization, cauterization, fulguration and total or partial cystectomy should be considered [ 6 , 11 , 49 ].

Pharmacological treatments Currently, there are no specific antiviral treatments with strong evidence of clinical efficacy against BKV. Adoptive cell therapy Although pharmacological therapies and prophylactic options are available to treat viral infections, they remain limited and ineffective due in part to drug resistance, drug related toxicities and morbidities notably acute kidney injury and myelosuppression [ 1 , 78 , 79 ].

VSTs The preliminary practices of adoptive T cell transfer were based on nonspecific donor lymphocyte infusions DLIs which led to restoring antiviral immunity with promising results. Table 3 Different methods for generation of VST. Ultimately expansion of T cells using IL Different practices for the generation of multivirus-specific T cells in one single step have been established.

Third-party VST can be utilize for these patients. Mesenchymal stromal cells In recent years, Mesenchymal stromal cells MSCs have captured significant interest in regenerative medicine because of their potential immunomodulatory effects, low immunogenicity and wound healing abilities [ 89 , 90 ].

Disclosure of conflict of interest None. References 1. Adoptive T cell therapystrategies for viral infections in patients receiving haematopoietic stem cell transplantation. Houghtelin A, Bollard CM. Virus-specific T cells for the immunocompromised patient. Front Immunol. Copelan EA. Hematopoietic stem-cell transplantation. N Engl J Med. Hematopoietic stem cell transplantation: clinical use and perspectives.

Biol Res. Strategies of adoptive T-cell transfer to treat refractory viral infections post allogeneic stem cell transplantation. J Hematol Oncol. Hemorrhagic cystitis in a cohort of pediatric transplantations: incidence, treatment, outcome, and risk factors. Biol Blood Marrow Transplant. Presentation of BK polyomavirus-associated hemorrhagic cystitis after allogeneic hematopoietic cell transplantation.

Blood Adv. Hemorrhagic cystitis after allogeneic hematopoietic cell transplantation: risk factors, graft source and survival. Bone Marrow Transplant. ECIL guidelines for the prevention, diagnosis and treatment of BK polyomavirus-associated haemorrhagic cystitis in haematopoietic stem cell transplant recipients.

J Antimicrob Chemother. Schneidewind L, Neumann T. Comparison of intravenous or intravesical cidofovir in the treatment of BK polyomavirus-associated hemorrhagic cystitis following adult allogeneic stem cell transplantation-A systematic review. Transpl Infect Dis.

BK polyomavirus: clinical aspects, immune regulation, and emerging therapies. Clin Microbiol Rev. Polyoma virus in transplant recipients.

Hemorrhagic cystitis after allogeneic hematopoietic stem cell transplants is the complex result of BK virus infection, preparative regimen intensity and donor type. Incidence, clinical outcome, and management of virus-induced hemorrhagic cystitis in children and adolescents after allogeneic hematopoietic cell transplantation.

Human polyomavirus reactivation: disease pathogenesis and treatment approaches. Clin Dev Immunol. Polyomavirus BK infection in blood and marrow transplant recipients. Boothpur R, Brennan DC. Human polyoma viruses and disease with emphasis on clinical BK and JC. J Clin Virol. Hirsch H, Pergam S. Human adenovirus, polyomavirus, and parvovirus infections in patients undergoing hematopoietic stem cell transplantation.

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Association between a high BK virus load in urine samples of patients with graft-versus-host disease and development of hemorrhagic cystitis after hematopoietic stem cell transplantation.

J Clin Microbiol. BK virus disease after allogeneic stem cell transplantation: a cohort analysis. Challenges and opportunities in radiation-induced hemorrhagic cystitis.

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Int Urol Nephrol. Efficacy and safety of ciprofloxacin for prophylaxis of polyomavirus BK virus-associated hemorrhagic cystitis in allogeneic hematopoietic stem cell transplantation recipients. Association of BK virus with failure of prophylaxis against hemorrhagic cystitis following bone marrow transplantation.

Application of fibrin glue to damaged bladder mucosa in a case of BK viral hemorrhagic cystitis. Current applications of fibrin sealant in urologic surgery.

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The use of hyperbaric oxygen therapy in the treatment of hemorrhagic cystitis after allogeneic stem cell transplantation from an unrelated donor. Int J Hematol. Hyperbaric oxygen therapy of an adolescent stem cell transplantation recipient with hemorrhagic cystitis and BK virus.

Case Rep Pulmonol. Successful hyperbaric oxygen therapy for refractory BK virus-associated hemorrhagic cystitis after cord blood transplantation. Hyperbaric oxygen therapy in BKV-associated hemorrhagic cystitis refractory to intravenous and intravesical cidofovir: case report and review of literature. Leuk Res. The use of hyperbaric oxygen therapy for refractory hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation.

Urological management medical and surgical of BK-virus associated haemorrhagic cystitis in children following haematopoietic stem cell transplantation. Cancer Ther Oncol Int J. Significance of urological surgical treatment for viral hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation.

Hinyokika Kiyo. Cidofovir for BK virus-associated hemorrhagic cystitis: a retrospective study. Clin Infect Dis. De Clercq E. Clinical potential of the acyclic nucleoside phosphonates cidofovir, adefovir, and tenofovir in treatment of DNA virus and retrovirus infections.

Activities of different classes of acyclic nucleoside phosphonates against BK virus in primary human renal cells. Antimicrob Agents Chemother. Successful treatment of BK virus hemorrhagic cystitis HC post allogenic hematopoietic stem cell transplantation with low dose cidofovir.

J Assoc Physicians India. Efficacy of cidofovir in treatment of BK virus-induced hemorrhagic cystitis in allogeneic hematopoietic cell transplant recipients. Treatment of BK virus-associated hemorrhagic cystitis with low-dose intravenous cidofovir in patients undergoing allogeneic hematopoietic cell transplantation. Korean J Intern Med. Mackey MC. Intravesicular cidofovir for the treatment of polyomavirus-associated hemorrhagic cystitis. Ann Pharmacother.

Cidofovir bladder instillation for the treatment of BK hemorrhagic cystitis after allogeneic stem cell transplantation. Am J Hematol. Cidofovir treatmenf for hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation for high risk hematological malignancies. Cidofovir in the treatment of BK virus-associated hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation. Ether lipid ester derivatives of cidofovir inhibit polyomavirus BK replication in vitro.

Brincidofovir: understanding its unique profile and potential role against adenovirus and other viral infections. Future Microbiol. Management of BK-virus infection-Swedish recommendations. This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice and cookie policy. Abstract Available from publisher site using DOI.

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This ability helps to use this construct as a good reporter since it can infect human cells. The activity of Rluc was strongly detected in Vero and Cos-1 cells transfected with rBKV-Rluc-myc-2A-VP2 construct, indicating the production of a functional enzyme driven by the native late promoter.

As a concluding remark, a potential infectious rBKV that can express foreign antigens such as Rluc was generated successfully. The proposed strategy would be useful to engineer recombinant forms of rBKV with many potential applications including development of antiviral assay for new drugs, human vaccines and gene delivery systems for immunotherapeutic or cell transduction. Full text links Read article at publisher's site DOI : Similar Articles To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation.

Development of infectious recombinant BK virus. Update on BK virus entry and intracellular trafficking. Joining Europe PMC.